The Wang laboratory studies pathological and metabolic changes in cardiovascular diseases, including hyperlipidemia, hyperglycemia, hyperinsulinemia, hyperhomocysteinemia, obesity, vascular inflammation, diabetes, stroke, peripheral artery disease, myocardial infarction, and chronic kidney disease. Researches focus on investigating the effect and underlying mechanism of metabolic disorder on 1) Atherosclerosis and vascular inflammation, 2) Endothelial function, 3), Monocyte epitope mapping/polarization, 4) HDL metabolism, 5) Epigenetic modification, and 6) Gene and stem cell therapy. We use dynamic state-of-art technologies to dissect disease mechanism and identify potential therapeutic targets. Frequently used research approaches include metabolomics, transcriptomics, RNA-Seq, CHIP-Seq, chemical, biochemical, immunological and pathophysiological approaches, microsurgery models for various vascular disease and thrombosis, transgenic and gene knock-out mice.