Research output per year
Research output per year
Personal profile
Professional Information
Lee lab focuses on computational epigenetics in cancer and aging. I am interested in identifying somatic epi-mutations in early-stage cancer and molecular-level subtypes using comprehensive multi-omics data analysis. The objective is to use this research to optimize clinically actional biomarkers and develop machine learning models to predict cancer typing, subtyping, matching therapeutics, and predicting relapse or metastasis. We pursue cutting-edge technologies, including single-cell multi-omics data, single-cell spatial transcriptomics, and proteomics, to identify predictive epigenetic signatures and understand the cancer microenvironment. We aim to design machine learning models to predict epigenetic and image biomarkers for early diagnostics and prognostics and recommend therapeutic options in cancer and neurodegenerative diseases.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Correction to: Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Zhu, Y., Lee, H., White, S., Weimer, A. K., Monte, E., Horning, A., Nevins, S. A., Esplin, E. D., Paul, K., Krieger, G., Shipony, Z., Chiu, R., Laquindanum, R., Karathanos, T. V., Chua, M. W. Y., Mills, M., Ladabaum, U., Longacre, T., Shen, J. & Jaimovich, A. & 6 others, , Feb 2025, In: Nature Cancer. 6, 2, p. 404 1 p.Research output: Contribution to journal › Comment/debate
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Genome Assembly of Arctica islandica, the Longest-Lived Non-Colonial Animal Species
Gerhard, G. S., Allard, J. B., Kaniper, S., Lynch, D., Lee, H. & Kumar, S., Feb 27 2025, In: Animals. 15, 5, 690.Research output: Contribution to journal › Article › peer-review
Open Access -
Correction to: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP) (Nature Cell Biology, (2023), 25, 8, (1089-1100), 10.1038/s41556-023-01194-w)
HuBMAP Consortium, May 2024, In: Nature Cell Biology. 26, 5, p. 839 1 p.Research output: Contribution to journal › Comment/debate
1 Scopus citations -
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Zhu, Y., Lee, H., White, S., Weimer, A. K., Monte, E., Horning, A., Nevins, S. A., Esplin, E. D., Paul, K., Krieger, G., Shipony, Z., Chiu, R., Laquindanum, R., Karathanos, T. V., Chua, M. W. Y., Mills, M., Ladabaum, U., Longacre, T., Shen, J. & Jaimovich, A. & 6 others, , Oct 2024, In: Nature Cancer. 5, 11, p. 1697-1712 16 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Esplin, E. D., Hanson, C., Wu, S., Horning, A. M., Barapour, N., Nevins, S. A., Jiang, L., Contrepois, K., Lee, H., Guha, T. K., Hu, Z., Laquindanum, R., Mills, M. A., Chaib, H., Chiu, R., Jian, R., Chan, J., Ellenberger, M., Becker, W. R. & Bahmani, B. & 15 others, , Nov 2024, In: Nature Cancer. 5, 11, p. 1737-1753 17 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Press/Media
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Fox Chase Cancer Center's Cancer Epigenetics Institute to Present Data From Ongoing Collaboration at biomodal Workshop at AACR Annual Meeting
Whetstine, J. R., Lee, H., Bellacosa, A. & Duy, C.
04/18/25
1 item of Media coverage
Press/Media
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Fox Chase Cancer Center Details Findings in Life Sciences (Epigenetic Balance Ensures Mechanistic Control Of Mll Amplification and Rearrangement)
Whetstine, J. R., Duy, C. & Lee, H.
12/14/23
1 item of Media coverage
Press/Media
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