Research output per year
Research output per year
Personal profile
Research interests
We study RNA regulators in stem cell fate regulations and cancer.
The Luo laboratory studies the mechanisms controlling hematopoietic stem cell fate choices in normal and diseases, with an overarching goal to develop novel therapeutic strategies for hematological diseases associated with stem cell defects. We are specifically interested in understanding how RNA regulators, including RNA modification and other novel disease-relevant RNA binding proteins, impact these processes. We use multi-disciplinary approaches, including mouse genetics, CRISPR genome engineering, multicolor flow cytometry, confocal microscope, and single-cell profiling technologies to tackle the following fundamental questions.
Blood stem cell fate decisions
What drives stem cell fate control in normal versus malignant contexts?
What intrinsic and extrinsic factors determine stem cell fates?
Can these regulators be leveraged for therapeutics against diseases?
Mechanistic role of RNA regulators
How does post-transcriptional regulation impact stem cell fates in normal and disease?
The molecular mechanisms by which RNA regulators influence stem cell fate decisions?
URL
https://www.luolab-fccc.com/
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Collaborations and top research areas from the last five years
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Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility (Nature Communications, (2024), 15, 1, (9432), 10.1038/s41467-024-53628-0)
Gao, V. R., Yang, R., Das, A., Luo, R., Luo, H., McNally, D. R., Karagiannidis, I., Rivas, M. A., Wang, Z. M., Barisic, D., Karbalayghareh, A., Wong, W., Zhan, Y. A., Chin, C. R., Noble, W. S., Bilmes, J. A., Apostolou, E., Kharas, M. G., Béguelin, W. & Viny, A. D. & 4 others, , Dec 2025, In: Nature Communications. 16, 1, 684.Research output: Contribution to journal › Comment/debate
Open Access -
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L
Feng, W., Ladewig, E., Lange, M., Salsabeel, N., Zhao, H., Lee, Y. S., Gopalan, A., Luo, H., Kang, W., Fan, N., Rosiek, E., de Stanchina, E., Chen, Y., Carver, B. S., Leslie, C. S. & Sawyers, C. L., Sep 2025, In: Nature Genetics. 57, 9, p. 2177-2191 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A dual-receptor T-cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML
Dao, T., Xiong, G., Mun, S. S., Meyerberg, J., Korontsvit, T., Xiang, J., Cui, Z., Chang, A. Y., Jarvis, C., Cai, W., Luo, H., Pierson, A., Daniyan, A., Yoo, S., Takao, S., Kharas, M., Kentsis, A., Liu, C. & Scheinberg, D. A., Feb 8 2024, In: Blood. 143, 6, p. 507-521 15 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Gao, V. R., Yang, R., Das, A., Luo, R., Luo, H., McNally, D. R., Karagiannidis, I., Rivas, M. A., Wang, Z.-M., Barisic, D., Karbalayghareh, A., Wong, W., Zhan, Y. A., Chin, C. R., Noble, W. S., Bilmes, J. A., Apostolou, E., Kharas, M. G., Beguelin, W. & Viny, A. D. & 4 others, , Nov 1 2024, In: Nature Communications. 15, 1, p. 9432 15 p., 9432.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Dotting Out AML by Targeting Fibrillarin
Luo, H. & Kharas, M. G., Sep 1 2024, In: Cancer Research. 84, 17, p. 2759-2760 2 p.Research output: Contribution to journal › Comment/debate
5 Scopus citations
Press/Media
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AMERICAN SOCIETY OF HEMATOLOGY ANNOUNCES 2025 SCHOLAR AWARD RECIPIENTS
01/17/25
1 item of Media coverage
Press/Media