Personal profile
Personal profile
Treatment Philosophy
I am excited to be a part of the gynecologic cancer patient care team at Fox Chase Cancer Center. I chose to work at Fox Chase to provide comprehensive, cutting-edge oncologic care by translating advances in research directly into my clinical practice.
As a gynecologic oncologist, I specialize in the surgical and medical management of tumors of the uterus, cervix, ovary, fallopian tube, vulva and vagina. I have extensive experience with complex open, laparoscopic and robotic surgery, which allows me to tailor a surgical plan based upon a patient’s needs and preferences. I also have expertise in administering intravenous and intraperitoneal chemotherapy for gynecologic malignancies. As a member of the multidisciplinary gynecologic cancer patient care team, I work closely with my colleagues in medical and radiation oncology to develop a comprehensive treatment plan that offers the best chance of cure for each patient.
I appreciate the challenges and commitment necessary to care for cancer patients. I understand that a cancer diagnosis can be overwhelming for patients and their families, and I always treat patients how I would want my family members to be treated: with honesty and compassion. I devote the time necessary to educate my patients on their options so they are best able to make an informed decision about their treatment.
Professionally, my research interests focus on endometriosis-associated ovarian cancer and hereditary ovarian cancer, including those resulting from BRCA1 or 2 mutations. The abundant resources available at Fox Chase, as well as my research experiences during my postdoctoral fellowship at the Magee-Womens Research Institute and as a clinical fellow at the University of Pennsylvania allow for me to participate in translational research and investigate innovative therapies to improve the quality of life for women with gynecologic malignancies.
Treatment Focus
Minimally invasive surgery (laparoscopy and robotic surgery); endometrial cancer and hyperplasia; cervical cancer and dysplasia; vulvar cancer and dysplasia; vaginal cancer and dysplasia; gestational trophoblastic disease; surgical management of pelvic masse
Areas of Expertise
Endometrial (Uterine) Cancer, Vulvar Cancer, Cervical Cancer, Uterine Sarcoma, Ovarian & Primary Peritoneal Cancer
Research interests
- Fertility and gynecologic cancers
- Endometriosis-related ovarian cancer
- Hereditary ovarian cancer
- Immunotherapy and ovarian cancer
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Collaborations and top research areas from the last five years
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Vaginal Cancer, Version 2.2026, NCCN Clinical Practice Guidelines In Oncology
Abu-Rustum, N. R., Campos, S. M., Amarnath, S., Arend, R., Barber, E., Bradley, K., Brooks, R., Chino, J., Chon, H. S., Crispens, M. A., Damast, S., Fisher, C. M., Frederick, P., Gaffney, D. K., Gaillard, S., Giuntoli, R., Glaser, G., Glaser, S., Howitt, B. E. & Kendra, K. & 21 others, , Mar 1 2026, In: Journal of the National Comprehensive Cancer Network : JNCCN. 24, 3, p. 101-126 26 p.Research output: Contribution to journal › Article › peer-review
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Cervical Cancer, Version 2.2026, NCCN Clinical Practice Guidelines In Oncology: Cervical Cancer, Version 2.2026
Abu-Rustum, N. R., Campos, S. M., Amarnath, S., Arend, R., Barber, E., Bradley, K., Brooks, R., Chino, J., Chon, H. S., Crispens, M. A., Damast, S., Fisher, C. M., Frederick, P., Gaffney, D. K., Gaillard, S., Giuntoli, R., Glaser, S., Howitt, B. E., Kendra, K. & Landrum, L. & 22 others, , Dec 2025, In: Journal of the National Comprehensive Cancer Network. 23, 12, p. 549-573 25 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Juntas Contra el Virus del Papiloma Humano: protocol for a pilot randomized controlled trial of an HPV self-sampling intervention for underscreened Latinas
Fang, C. Y., Cora-Cruz, M., Koirala, P., Perez, S., Li, M., Egleston, B. L., Chen, Y., Mantia-Smaldone, G. & Martinez, O., May 10 2025, In: Pilot and Feasibility Studies. 11, 1, p. 65 65.Research output: Contribution to journal › Article › peer-review
Open Access -
Uterine Neoplasms, Version 3.2025 Featured Updates to the NCCN Guidelines®
Abu-Rustum, N. R., Campos, S. M., Amarnath, S., Arend, R., Barber, E., Bradley, K., Brooks, R., Chino, J., Chon, H. S., Crispens, M. A., Damast, S., Fisher, C. M., Frederick, P., Gaffney, D. K., Gaillard, S., Giuntoli, R., Glaser, S., Howitt, B. E., Landrum, L. & Lea, J. & 21 others, , Aug 2025, In: JNCCN Journal of the National Comprehensive Cancer Network. 23, 8, p. 284-291 8 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FRα)–targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer
Richardson, D. L., Moore, K. N., Vergote, I., Gilbert, L., Martin, L. P., Mantia-Smaldone, G. M., Castro, C. M., Provencher, D., Matulonis, U. A., Stec, J., Wang, Y., Method, M. & O'Malley, D. M., Jun 2024, In: Gynecologic Oncology. 185, p. 186-193 8 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations
Press/Media
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Fox Chase Cancer Center Researchers Publish New Data on Cervical Cancer (Juntas Contra el Virus del Papiloma Humano: protocol for a pilot randomized controlled trial of an HPV self-sampling intervention for underscreened Latinas)
Mantia-Smaldone, G. M., Fang, C. & Egleston, B.
05/27/25
1 item of Media coverage
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Philadelphia Magazine Names 142 Fox Chase Cancer Center Physicians 'Top Doctors'
Mantia-Smaldone, G. M., Vijayvergia, N., Borghaei, H., Weiss, S. E., Kumar, R., Khanal, R., Frosch, Z. A., Flieder, D. B., Chen, D. Y., Plimack, E. R., Manley, C. J., Nejati, R. M., Ehya, H., Kutikov, A., Sherry, D. R., Hallman, M. A., Uzzo, R. G., Patel, S. A., Daly, M., Viterbo, R., Curcillo, P. G., Bleicher, R., Edelman, M., Greco, S. H., Miyamoto, C. T., von Mehren, M., Chwistek, M., Galloway, T. J., Jain, A., Meyer, J. E., Castellanos, J. A., Farma, J. M., Weinberg, D. S., Friedberg, J., Wasik, M. A., Zibelman, M. R., Wang, Y. L., Astsaturov, I., Olszanski, A. J., Simhan, J., Friedlander, J. I., Cohn, J., Sterious, S., Wei, S., Giri, A. P., Berman, A. T., Loren, D. E., McCue, P. A., Abdelmessieh, P., Ahmad, D., Messmer, M., Ghiraldi, E. M., Horwitz, E. M., Correa, A. F., Yu, J. Q., Smaldone, M. C., Villano, A. M., Aphale, A., McShane, M. M., Kumar, S. S., Walchak, A., Wookey, V. B., Wong, J. K., Nakhoda, S. K., Bauman, J., Williams, A. D., Hall, M. J., Fung, H. C., Reddy, S. S. & Geynisman, D.
04/22/25
1 item of Media coverage
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These Are the Main Line Region’s Top Doctors in 2024
Mantia-Smaldone, G. M., Chen, D. Y., Patel, S. A., Simhan, J., Cohn, J., Ghiraldi, E. M., Miller, S. M., Sterious, S. & Cann, C. G.
12/17/24
1 item of Media coverage
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Cervical cancer screening rates are dropping. Here's why that's an issue.
06/14/24
2 items of Media coverage
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310 Temple Health Physicians Named 'Top Doctors' by Philadelphia Magazine
Mantia-Smaldone, G. M., Vijayvergia, N., Borghaei, H., Weiss, S. E., Kumar, R., Khanal, R., Flieder, D. B., Chen, D. Y., Plimack, E. R., Dotan, E., Manley, C. J., Hernandez, E., Nejati, R. M., Ehya, H., Kutikov, A., Hallman, M. A., Uzzo, R. G., Patel, S. A., Viterbo, R., Curcillo, P. G., Bleicher, R., Edelman, M., Greco, S. H., Miyamoto, C. T., von Mehren, M., Chwistek, M., Jain, A., Meyer, J. E., Castellanos, J. A., Farma, J. M., Weinberg, D. S., Friedberg, J., Wasik, M. A., Zibelman, M. R., Wang, Y. L., Astsaturov, I., Olszanski, A. J., Simhan, J., Friedlander, J. I., Cohn, J., Sterious, S., Galloway, T. J., Wei, S., Giri, A. P., Berman, A. T., Loren, D. E., McCue, P. A., Abdelmessieh, P., Ahmad, D., Messmer, M., Horwitz, E. M., Correa, A. F., Yu, J. Q., Smaldone, M. C., Villano, A. M., Aphale, A., McShane, M. M., Kumar, S. S., Walchak, A., Nakhoda, S. K., Erkmen, C., Bauman, J., Williams, A. D., Hall, M. J., Fung, H. C., Reddy, S. S. & Geynisman, D.
05/22/24
1 item of Media coverage
Press/Media