Research output per year
Research output per year
Personal profile
Research interests
- In our lab, we focus on identifying the molecular mechanisms that control stem cell differentiation toward specific cardiac lineages. We aim to decipher signaling pathways, transcriptional and epigenetic mechanisms that regulate specific cardiac cell fates. We want to use this knowledge to identify mechanisms and factors important for cardiac cell development and to provide new tools to design stem cell-based strategies for cardiac repair. These are our current research interests:
- Transcription regulation during cardiomyocyte differentiation
- Mechanisms altered in congenital heart disease
- Heart bioengineering
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Collaborations and top research areas from the last five years
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A retinoic acid:YAP1 signaling axis controls atrial lineage commitment
Abraham, E., Kostina, A., Volmert, B., Roule, T., Huang, L., Yu, J., Williams, A. E., Megill, E., Douglas, A., Pericak, O. M., Morris, A., Stronati, E., Larrinaga-Zamanillo, A., Fueyo, R., Zubillaga, M., Andrake, M. D., Akizu, N., Aguirre, A. & Estaras, C., May 27 2025, In: Cell Reports. 44, 5, p. 115687 115687.Research output: Contribution to journal › Article › peer-review
Open Access -
DNMT3B-Mediated Epigenetic Reprogramming Induces Cardiomyocyte Dedifferentiation and Proliferation, Enhancing Post-MI Cardiac Regeneration
Gurrala, C., Cohen, M., Kubo, H., Joladarashi, D., Abraham, E., Mallaredy, V., Cheng, Z., McMullan, E., Wittmann, C., Thakur, A., Cimini, M., Truongcao, M., Benedict, C., Ghosh, J., Estaras, C. & Kishore, R., Aug 1 2025, In: Circulation Research. 137, SUPPL_1, 2 p., Thu096.Research output: Contribution to journal › Meeting Abstract › peer-review
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YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast
Abraham, E., Roule, T., Douglas, A., Megill, E., Pericak, O. M., Howe, J. E., Choya-Foces, C., Garbincius, J. F., Cohen, H. M., Roig-Flórez, P., Zubillaga, M., Andrake, M. D., Kim, S., Elrod, J. W., Akizu, N. & Estaras, C., Jun 17 2025, (bioRxiv : the preprint server for biology).Research output: Working paper › Preprint
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Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program
Lazaropoulos, M. P., Gibb, A. A., Chapski, D. J., Nair, A. A., Reiter, A. N., Roy, R., Eaton, D. M., Bedi, K. C., Margulies, K. B., Wellen, K. E., Estarás, C., Vondriska, T. M. & Elrod, J. W., Jul 2024, In: Nature Cardiovascular Research. 3, 7, p. 869-882 14 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation
Abraham, E., Zubillaga, M., Roule, T., Stronati, E., Akizu, N. & Estaras, C., Jun 2024, In: Journal of Visualized Experiments. 2024-June, 208, e66866.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Press/Media
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YAP1 molecule essential to development of gastruloids using embryonic stem cells; findings may have implications for cancer
02/10/22
3 items of Media coverage
Press/Media