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Christopher W. Schultz

Christopher W. Schultz, PhD

Assistant Professor, Assistant Professor, Cancer and Cellular Biology, Lewis Katz School of Medicine

 https://orcid.org/0000-0001-5731-2847
20192026

Research activity per year

Personal profile

Research interests

I am interested in exploring the causes of Small Cell Lung Cancer (SCLC), as well as developing novel therapies for both SCLC and other recalcitrant cancers. I am currently studying unique vulnerabilities for SCLC governed by neuroendocrine differentiation as well as faulty cell cycle transition dynamics.

Lab Overview

The Schultz lab aims to further understand small cell lung cancer and unique vulnerabilities associated with neuroendocrine differentiation and characteristic mutations present in small cell lung cancer. All work at the Schultz lab is designed to be translationally relevant, with every project aimed at near-term translatability to the clinic if successful.

URL

https://www.foxchase.org/christopher-william-schultz

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Collaborations and top research areas from the last five years

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  • Blockade of Tumor-intrinsic Tgf-β Signaling Drives Hyperprogression in Small Cell Lung Cancer

    Schroeder, B. A., Mohindroo, C., Meinhardt, A.-L., Takahashi, N., Zhang, Y., Lee, M.-J., Sahoo, S., Donahue, R. N., Kumar, R., Nirula, M., Yang, Y., Rastogi, S., Sato, N., Lee, S., Tsai, Y.-T., Zhuang, S., Kazi, A., Huang, Y., Desai, P. & Nichols, S. & 21 others, Sciuto, L., Pinkiert, D., Chrisafis, G., Greenberg, M., Biery, D. N., Al-Marayaty, R., Yang, H. H., Lee, M. P., Schultz, C. W., El Meskini, R., Atkinson, D., Fousek, K., Gulley, J. L., Schlom, J., Sato, M., Shrestha, R. L., Sharma, A. K., Jolly, M. K., Palena, C., Wakefield, L. M. & Thomas, A., Apr 22 2026, (E-pub ahead of print) In: Cancer Discovery.

    Research output: Contribution to journal › Article › peer-review

  • Stiffness-dependent alveolar type II cell senescence in idiopathic pulmonary fibrosis

    Lin, C.-R., Woranam, K., Hayek, H., Jeger, J., Karim, L., Kosmider, B., Kaminski, R., Schultz, C. W., Bolla, S., Marchetti, N., Criner, G. J. & Bahmed, K., Apr 25 2026, (E-pub ahead of print) In: Cell Communication and Signaling.

    Research output: Contribution to journal › Article › peer-review

  • Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor

    Takahashi, N., Pongor, L., Agrawal, S. P., Shtumpf, M., Gurjar, A., Rajapakse, V. N., Shafiei, A., Schultz, C. W., Kim, S., Roame, D., Carter, P., Vilimas, R., Nichols, S., Desai, P., Figg Sr, W. D., Bagheri, M., Teif, V. B. & Thomas, A., Feb 25 2025, In: Genome Medicine. 17, 1, 16 p., 15.

    Research output: Contribution to journal › Article › peer-review

    4 Scopus citations

  • Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

    Schultz, C. W., Saha, S., Dhall, A., Zhang, Y., Desai, P., Pongor, L. S., Scheiblin, D. A., Magidson, V., Sun, Y., Redon, C., Kumar, S., Krishnamurthy, M., Dias, H. B., Aksenova, V., Giordano, E., Takahashi, N., Nirula, M., Arora, M., Tabe, C. & Thomas, M. & 10 others, Kumar, R., Arakawa, Y., Jo, U., Teicher, B. A., Aladjem, M. I., Lockett, S., Dasso, M., Pommier, Y., Sharma, A. K. & Thomas, A., May 3 2025, (bioRxiv : the preprint server for biology).

    Research output: Working paper › Preprint

  • Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer

    Schultz, C. W., Saha, S., Dhall, A., Zhang, Y., Desai, P., Pongor, L. S., Scheiblin, D. A., Magidson, V., Shuklah, R. P., Sebastian, R., Vekariya, U. M., Ahmed, S., Sun, Y., Redon, C., Kumar, S., Krishnamurthy, M., Dias, H. B., Aksenova, V., Giordano, E. & Takahashi, N. & 16 others, Nirula, M., Arora, M., Tabe, C., Thomas, M. S., Kumar, R., Arakawa, Y., Jo, U., Skorski, T., Teicher, B. A., Shreshta, R., Aladjem, M. I., Lockett, S., Dasso, M., Pommier, Y., Sharma, A. K. & Thomas, A., Oct 28 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 43, p. e2503387122 e2503387122.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations
View all 33 Research outputs