Christopher W. Schultz

Christopher W. Schultz, PhD

Assistant Professor, Assistant Professor, Cancer and Cellular Biology, Lewis Katz School of Medicine

Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
Calculated based on number of publications stored in Pure and citations from Scopus
20192025

Research activity per year

Personal profile

Research interests

I am interested in exploring the causes of Small Cell Lung Cancer (SCLC), as well as developing novel therapies for both SCLC and other recalcitrant cancers. I am currently studying unique vulnerabilities for SCLC governed by neuroendocrine differentiation as well as faulty cell cycle transition dynamics.

Lab Overview

The Schultz lab aims to further understand small cell lung cancer and unique vulnerabilities associated with neuroendocrine differentiation and characteristic mutations present in small cell lung cancer. All work at the Schultz lab is designed to be translationally relevant, with every project aimed at near-term translatability to the clinic if successful.

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Collaborations and top research areas from the last five years

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  • Metastatic organotropism in small cell lung cancer

    Krishnamurthy, M., Dhall, A., Sahoo, S., Schultz, C. W., Baird, M. A., Desai, P., Odell, J., Takahashi, N., Nirula, M., Zhuang, S., Huang, Y., Schroeder, B., Zhang, Y., Thomas, M. S., Redon, C., Robinson, C., Thang, L., Ileva, L., Patel, N. L. & Kalen, J. D. & 18 others, Varlet, A.-A., Zuela-Sopilniak, N., Jha, A., Wangsa, D., Butcher, D., Morgan, T., Afzal, A. N., Chari, R., Baktiar, K., Kumar, S., Pongor, L., Difilippantonio, S., Aladjem, M. I., Pommier, Y., Jolly, M. K., Lammerding, J., Sharma, A. K. & Thomas, A., Jan 24 2025, (bioRxiv : the preprint server for biology).

    Research output: Working paperPreprint

  • Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

    Desai, P., Takahashi, N., Kumar, R., Nichols, S., Malin, J., Hunt, A., Schultz, C., Cao, Y., Tillo, D., Nousome, D., Chauhan, L., Sciuto, L., Jordan, K., Rajapakse, V., Tandon, M., Lissa, D., Zhang, Y., Kumar, S., Pongor, L. & Singh, A. & 38 others, Schroder, B., Sharma, A. K., Chang, T., Vilimas, R., Pinkiert, D., Graham, C., Butcher, D., Warner, A., Sebastian, R., Mahon, M., Baker, K., Cheng, J., Berger, A., Lake, R., Abel, M., Krishnamurthy, M., Chrisafis, G., Fitzgerald, P., Nirula, M., Goyal, S., Atkinson, D., Bateman, N. W., Abulez, T., Nair, G., Apolo, A., Guha, U., Karim, B., El Meskini, R., Ohler, Z. W., Jolly, M. K., Schaffer, A., Ruppin, E., Kleiner, D., Miettinen, M., Brown, G. T., Hewitt, S., Conrads, T. & Thomas, A., Jun 18 2024, In: Cell Reports Medicine. 5, 6, p. 101610 101610.

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations
  • A Novel 3DNA® Nanocarrier effectively delivers payloads to pancreatic tumors

    McCarthy, G. A., Jain, A., Di Niro, R., Schultz, C. W., Jiang, W., Yeo, C. J., Bowers, J., Finan, J., Rhodes, K., Casta, L., Hou, V., Stefanoni, A., Brown, S. Z., Nevler, A., Agostini, L. C., Getts, L., Getts, R. & Brody, J. R., Jun 2023, In: Translational Oncology. 32, p. 101662 101662.

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations
  • ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer

    Schultz, C. W., Zhang, Y., Elmeskini, R., Zimmermann, A., Fu, H., Murai, Y., Wangsa, D., Kumar, S., Takahashi, N., Atkinson, D., Saha, L. K., Lee, C.-F., Elenbaas, B., Desai, P., Sebastian, R., Sharma, A. K., Abel, M., Schroeder, B., Krishnamurthy, M. & Kumar, R. & 6 others, Roper, N., Aladjem, M., Zenke, F. T., Ohler, Z. W., Pommier, Y. & Thomas, A., Aug 7 2023, In: EMBO molecular medicine. 15, 8, p. e17313 e17313.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    16 Scopus citations
  • Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer A Randomized Clinical Trial

    Takahashi, N., Hao, Z., Villaruz, L. C., Zhang, J., Ruiz, J., Petty, W. J., Mamdani, H., Riess, J. W., Nieva, J., Pachecho, J. M., Fuld, A. D., Shum, E., Chauhan, A., Nichols, S., Shimellis, H., Mcglone, J., Sciuto, L., Pinkiert, D., Graham, C. & Shelat, M. & 18 others, Kattappuram, R., Abel, M., Schroeder, B., Upadhyay, D., Krishnamurthy, M., Sharma, A. K., Kumar, R., Malin, J., Schultz, C. W., Goyal, S., Redon, C. E., Pommier, Y., Aladjem, M. I., Gore, S. D., Steinberg, S. M., Vilimas, R., Desai, P. & Thomas, A., Dec 2023, In: JAMA Oncology. 9, 12, p. 1669-1677 9 p.

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations