Beata Kosmider

2025

Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells

Lin, C.-R., Hayek, H., Simborio, H., Karim, L., Bahmed, K., Bolla, S., Marchetti, N., Criner, G. J., Tian, Y. & Kosmider, B., Jan 24 2025, (E-pub ahead of print) In: Aging and Disease.

Research output: Contribution to journal › Article › peer-review

2024

Corrigendum: CD8 T cell response and its released cytokine IFN-γ are necessary for lung alveolar epithelial repair during bacterial pneumonia (Frontiers in Immunology, (2023), 14, (1268078), 10.3389/fimmu.2023.1268078)

Zhang, X., Ali, M., Pantuck, M. A., Yang, X., Lin, C. R., Bahmed, K., Kosmider, B. & Tian, Y., 2024, In: Frontiers in Immunology. 15, p. 1446350 1446350.

Research output: Contribution to journal › Article › peer-review

Open Access

Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema

Simborio, H., Hayek, H., Kosmider, B., Elrod, J. W., Bolla, S., Marchetti, N., Criner, G. J. & Bahmed, K., Dec 2024, In: Cell Communication and Signaling. 22, 1, 562.

Research output: Contribution to journal › Article › peer-review

Open Access

The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis

Hayek, H., Rehbini, O., Kosmider, B., Brandt, T., Chatila, W., Marchetti, N., Criner, G. J., Bolla, S., Kishore, R., Bowler, R. P. & Bahmed, K., Apr 1 2024, In: American Journal of Respiratory Cell and Molecular Biology. 70, 4, p. 259-282 24 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2023

CD8 T cell response and its released cytokine IFN-γ are necessary for lung alveolar epithelial repair during bacterial pneumonia

Zhang, X., Ali, M., Pantuck, M. A., Yang, X., Lin, C. R., Bahmed, K., Kosmider, B. & Tian, Y., 2023, In: Frontiers in Immunology. 14, p. 1268078 1268078.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

Age-induced prostaglandin E₂ impairs mitochondrial fitness and increases mortality to influenza infection

Chen, J., Deng, J. C., Zemans, R. L., Bahmed, K., Kosmider, B., Zhang, M., Peters-Golden, M. & Goldstein, D. R., Dec 2022, In: Nature Communications. 13, 1, p. 6759 6759.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema

Karim, L., Lin, C. R., Kosmider, B., Criner, G., Marchetti, N., Bolla, S., Bowler, R. & Bahmed, K., Jul 2022, In: Biomedicines. 10, 7, 1497.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

Contribution of dipeptidyl peptidase 4 to non-typeable Haemophilus influenzae-induced lung inflammation in COPD

Kotnala, S., Kim, Y., Rajput, C., Reddyvari, H., Bolla, S., Marchetti, N. T., Kosmider, B., Bahmed, K. & Sajjan, U. S., Sep 2021, In: Clinical Science. 135, 17, p. 2067-2083 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR9 (Toll-Like Receptor 9)-Mediated Atherosclerosis

Li, J., Huynh, L., Cornwell, W. D., Tang, M. S., Simborio, H., Huang, J., Kosmider, B., Rogers, T. J., Zhao, H., Steinberg, M. B., Thu Thi Le, L., Zhang, L., Pham, K., Liu, C. & Wang, H., Feb 1 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41, 2, p. 839-853 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Expression of sars-cov-2 entry factors in human alveolar type ii cells in aging and emphysema

Lin, C. R., Bahmed, K., Simborio, H., Hayek, H., Bolla, S., Marchetti, N., Criner, G. J. & Kosmider, B., Jul 2021, In: Biomedicines. 9, 7, 779.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2020

Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling

Choi, W., Choe, S., Lin, J., Borchers, M. T., Kosmider, B., Vassallo, R., Limper, A. H. & Lau, G. W., Jul 1 2020, In: Mucosal Immunology. 13, 4, p. 637-651 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling

Wongtrakool, C., Ko, J., Jang, A. J., Grooms, K., Chang, S., Sylber, C., Kosmider, B., Bahmed, K., Blackburn, M. R., Sutliff, R. L., Michael Hart, C., Park, C., Nyunoya, T., Passineau, M. J., Lu, Q. & Kang, B. Y., Dec 25 2020, In: Journal of Biological Chemistry. 295, 52, p. 18051-18064 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

The common K333Q polymorphism in long-chain acyl-CoA dehydrogenase (LCAD) reduces enzyme stability and function

Beck, M. E., Zhang, Y., Bharathi, S. S., Kosmider, B., Bahmed, K., Dahmer, M. K., Nogee, L. M. & Goetzman, E. S., Sep 1 2020, In: Molecular Genetics and Metabolism. 131, 1-2, p. 83-89 7 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2019

Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity against Non-tuberculous Mycobacteria

Bai, X., Bai, A., Honda, J. R., Eichstaedt, C., Musheyev, A., Feng, Z., Huitt, G., Harbeck, R., Kosmider, B., Sandhaus, R. A. & Chan, E. D., 2019, In: Frontiers in Immunology. 10, JUN, p. 1417 1417.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema

Kosmider, B., Lin, C. R., Vlasenko, L., Marchetti, N., Bolla, S., Criner, G. J., Messier, E., Reisdorph, N., Powell, R. L., Madesh, M., Kelsen, S., Xander, N., Correll, K. A., Mason, R. J. & Bahmed, K., Jan 29 2019, In: Scientific Reports. 9, 1, p. 920 920.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

MiR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation

Moimas, S., Salton, F., Kosmider, B., Ring, N., Volpe, M. C., Bahmed, K., Braga, L., Rehman, M., Vodret, S., Graziani, M. L., Wolfson, M. R., Marchetti, N., Rogers, T. J., Giacca, M., Criner, G. J., Zacchigna, S. & Confalonieri, M., 2019, In: ERJ Open Research. 5, 4, 00138-2019.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Mitochondrial dysfunction in human primary alveolar type II cells in emphysema

Kosmider, B., Lin, C. R., Karim, L., Tomar, D., Vlasenko, L., Marchetti, N., Bolla, S., Madesh, M., Criner, G. J. & Bahmed, K., Aug 2019, In: eBioMedicine. 46, p. 305-316 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

S100A8 protects human primary alveolar type II cells against injury and emphysema

Lin, C. R., Bahmed, K., Criner, G. J., Marchetti, N., Tuder, R. M., Kelsen, S., Bolla, S., Mandapati, C. & Kosmider, B., Mar 2019, In: American Journal of Respiratory Cell and Molecular Biology. 60, 3, p. 299-307 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells

Bahmed, K., Boukhenouna, S., Karim, L., Andrews, T., Lin, J., Powers, R., Wilson, M. A., Lin, C. R., Messier, E., Reisdorph, N., Powell, R. L., Tang, H. Y., Mason, R. J., Criner, G. J. & Kosmider, B., Sep 1 2019, In: Cell Death and Disease. 10, 9, 638.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

The kinome of human alveolar type II and basal cells, and its reprogramming in lung cancer

Leach, S. M., Finigan, J., Vasu, V. T., Mishra, R., Ghosh, M., Foster, D., Mason, R. J., Kosmider, B., Hesson, E. F. & Kern, J. A., Oct 1 2019, In: American Journal of Respiratory Cell and Molecular Biology. 61, 4, p. 481-491 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema

Lin, C. R., Bahmed, K., Tomar, D., Marchetti, N., Criner, G. J., Bolla, S., Wilson, M. A., Madesh, M. & Kosmider, B., 2019, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 6, p. L791-L804

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol

Bahmed, K., Lin, C. R., Simborio, H., Karim, L., Aksoy, M., Kelsen, S., Tomar, D., Madesh, M., Elrod, J., Messier, E., Mason, R., Unterwald, E. M., Eisenstein, T. K., Criner, G. J. & Kosmider, B., Oct 2019, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 317, 4, p. L475-L485

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation

LaCanna, R., Liccardo, D., Zhang, P., Tragesser, L., Wang, Y., Cao, T., Chapman, H. A., Morrisey, E. E., Shen, H., Koch, W. J., Kosmider, B., Wolfson, M. R. & Tian, Y., May 1 2019, In: Journal of Clinical Investigation. 129, 5, p. 2107-2122 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

208 Scopus citations

2018

The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema

Tan, L. H., Bahmed, K., Lin, C. R., Marchetti, N., Bolla, S., Criner, G. J., Kelsen, S., Madesh, M. & Kosmider, B., Feb 23 2018, In: Scientific Reports. 8, 1, p. 3555 3555.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2017

K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer

Bikkavilli, R. K., Zerayesus, S. A., Van Scoyk, M., Wilson, L., Wu, P. Y., Baskaran, A., Tang, K., Raheem, S., Samuelson, B. A., Reddy, N. M., Reddy, S. P., Cool, C. D., Kosmider, B., Avasarala, S. & Winn, R. A., May 5 2017, In: Journal of Biological Chemistry. 292, 18, p. 7423-7434 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Lipidomic characterization and localization of phospholipids in the human lung

Zemski Berry, K. A., Murphy, R. C., Kosmider, B. & Mason, R. J., May 2017, In: Journal of Lipid Research. 58, 5, p. 926-933 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

RTP801 amplifies nicotinamide adenine dinucleotide phosphate oxidase-4-dependent oxidative stress induced by cigarette smoke

Hernández-Saavedra, D., Sanders, L., Perez, M. J., Kosmider, B., Smith, L. P., Mitchell, J. D., Yoshida, T. & Tuder, R. M., Jan 2017, In: American Journal of Respiratory Cell and Molecular Biology. 56, 1, p. 62-73 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers

Aksoy, M. O., Kim, V., Cornwell, W. D., Rogers, T. J., Kosmider, B., Bahmed, K., Barrero, C., Merali, S., Shetty, N. & Kelsen, S. G., May 2 2017, In: Respiratory Research. 18, 1, p. 78 78.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

2016

Cigarette smoke extract-exposed methicillin-resistant staphylococcus aureus regulates leukocyte function for pulmonary persistence

Kulkarni, R., Caskey, J., Singh, S. K., Paudel, S., Baral, P., Schexnayder, M., Kim, J., Kim, N., Kosmider, B., Ratner, A. J. & Jeyaseelan, S., Oct 2016, In: American Journal of Respiratory Cell and Molecular Biology. 55, 4, p. 586-601 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Cigarette smoke induces human epidermal receptor 2-dependent changes in epithelial permeability

Mishra, R., Foster, D., Vasu, V. T., Thaikoottathil, J. V., Kosmider, B., Chu, H. W., Bowler, R. P. & Finigan, J. H., Jun 2016, In: American Journal of Respiratory Cell and Molecular Biology. 54, 6, p. 853-864 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

DJ-1 modulates nuclear erythroid 2-related factor-2-mediated protection in human primary alveolar type II cells in smokers

Bahmed, K., Messier, E. M., Zhou, W., Tuder, R. M., Freed, C. R., Chu, H. W., Kelsen, S. G., Bowler, R. P., Mason, R. J. & Kosmider, B., Sep 2016, In: American Journal of Respiratory Cell and Molecular Biology. 55, 3, p. 439-449 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2014

A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution

Hartney, J. M., Stidham, T., Goldstrohm, D. A., Oberley-Deegan, R. E., Weaver, M. R., Valnickova-Hansen, Z., Scavenius, C., Benninger, R. K. P., Leahy, K. F., Johnson, R., Gally, F., Kosmider, B., Zimmermann, A. K., Enghild, J. J., Nozik-Grayck, E. & Bowler, R. P., Oct 1 2014, In: Circulation: Cardiovascular Genetics. 7, 5, p. 659-666 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

General parity between trio and pairwise breeding of laboratory mice in static caging

Kedl, R. M., Wysocki, L. J., Janssen, W. J., Born, W. K., Rosenbaum, M. D., Granowski, J., Kench, J. A., Fong, D. L., Switzer, L. A., Cruse, M., Huang, H., Jakubzick, C. V., Kosmider, B., Takeda, K., Stranova, T. J., Klumm, R. C., Delgado, C., Tummala, S., De Langhe, S. & Cambier, J. & 3 others, Haskins, K., Lenz, L. L. & Curran-Everett, D., Nov 15 2014, In: Journal of Immunology. 193, 10, p. 4757-4760 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Long-chain Acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction

Goetzman, E. S., Alcorn, J. F., Bharathi, S. S., Uppala, R., McHugh, K. J., Kosmider, B., Chen, R., Zuo, Y. Y., Beck, M. E., McKinney, R. W., Skilling, H., Suhrie, K. R., Karunanidhi, A., Yeasted, R., Otsubo, C., Ellis, B., Tyurina, Y. Y., Kagan, V. E., Mallampalli, R. K. & Vockley, J., Apr 11 2014, In: Journal of Biological Chemistry. 289, 15, p. 10668-10679 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

2013

FABP5 deficiency enhances susceptibility to H1N1 influenza a virus-induced lung inflammation

Gally, F., Kosmider, B., Weaver, M. R., Pate, K. M., Hartshorn, K. L. & Oberley-Deegan, R. E., Jul 1 2013, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 305, 1, p. L64-L72

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner

Messier, E. M., Day, B. J., Kleeberger, S. R., Tuder, R. M., Bowler, R. P., Chu, H. W., Mason, R. J. & Kosmider, B., May 2013, In: American Journal of Respiratory Cell and Molecular Biology. 48, 5, p. 559-567 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

Wei, Y., Gong, J., Thimmulappa, R. K., Kosmider, B., Biswal, S. & Duh, E. J., Sep 8 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. E3910-E3918

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke

Messier, E., Bahmed, K., Tuder, R. M., Chu, H. W., Bowler, R. & Kosmider, B., Apr 2013, In: Cell Death and Disease. 4, 4, p. e573 e573.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2012

Efficient and rapid isolation and purification of mouse alveolar type II epithelial cells.

Messier, E. M., Mason, R. J. & Kosmider, B., Aug 2012, In: Experimental Lung Research. 38, 7, p. 363-373 11 p.

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus

Kosmider, B., Messier, E. M., Janssen, W. J., Nahreini, P., Wang, J., Hartshorn, K. L. & Mason, R. J., Jun 6 2012, In: Respiratory Research. 13, 1, p. 43 43.

Research output: Contribution to journal › Article › peer-review

Open Access

131 Scopus citations

2011

Human alveolar epithelial cell injury induced by cigarette smoke

Kosmider, B., Messier, E. M., Chu, H. W. & Mason, R. J., Dec 7 2011, In: PLoS ONE. 6, 12, p. e26059 e26059.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Innate immune response to influenza A virus in differentiated human alveolar type II cells

Wang, J., Nikrad, M. P., Phang, T., Gao, B., Alford, T., Ito, Y., Edeen, K., Travanty, E. A., Kosmider, B., Hartshorn, K. & Mason, R. J., Sep 1 2011, In: American Journal of Respiratory Cell and Molecular Biology. 45, 3, p. 582-591 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

100 Scopus citations

2010

Apoptosis induced by ozone and oxysterols in human alveolar epithelial cells

Kosmider, B., Loader, J. E., Murphy, R. C. & Mason, R. J., Jun 2010, In: Free Radical Biology and Medicine. 48, 11, p. 1513-1524 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Structure-activity relationship and apoptosis induction in A549 cells by the potential anticancer compound cis-bis(3-aminoflavone)dichloroplatinum(II)

Kosmider, B., Anuels, S. A., Evenberg, D., Zyner, E., Bahmed, K., Osiecka, R. & Ochocki, J., 2010, In: Arzneimittel-Forschung/Drug Research. 60, 3, p. 149-156 8 p.

Research output: Contribution to journal › Article › peer-review

2008

Migratory activity of human breast cancer cells is modulated by differential expression of xanthine oxidoreductase

Fini, M. A., Orchard-Webb, D., Kosmider, B., Amon, J. D., Kelland, R., Shibao, G. & Wright, R. M., Oct 1 2008, In: Journal of Cellular Biochemistry. 105, 4, p. 1008-1026 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

2007

Fragile X repeats are potent inducers of complex, multiple site rearrangements in flanking sequences in Escherichia coli

Kosmider, B. & Wells, R. D., Dec 1 2007, In: DNA Repair. 6, 12, p. 1850-1863 14 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2006

Double-strand breaks in the myotonic dystrophy type 1 and the fragile X syndrome triplet repeat sequences induce different types of mutations in DNA flanking sequences in Escherichia coli

Kosmider, B. & Wells, R. D., Nov 2006, In: Nucleic Acids Research. 34, 19, p. 5369-5382 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Evaluation of P53 and BAX gene expression and induction of apoptosis and necrosis by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-diamminedichloroplatinum(II) (cis-DDP) in human lymphocytes

Kosmider, B., Zawlik, I., Liberski, P. P., Osiecka, R., Zyner, E., Ochocki, J. & Bartkowiak, J., Apr 30 2006, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 604, 1-2, p. 28-35 8 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2005

Comparison between the genotoxicity of cis-Pt(II) complex of 3-aminoflavone and cis-DDP in lymphocytes evaluated by the comet assay

Kosmider, B., Osiecka, R., Zyner, E. & Ochocki, J., 2005, In: Drug and Chemical Toxicology. 28, 2, p. 231-244 14 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Electrochemical genosensing of the interaction between the potential chemotherapeutic agent, cis-bis(3-aminoflavone)dichloroplatinum(II) and DNA in comparison with cis-DDP

Erdem, A., Kosmider, B., Osiecka, R., Zyner, E., Ochocki, J. & Ozsoz, M., Jul 15 2005, In: Journal of Pharmaceutical and Biomedical Analysis. 38, 4, p. 645-652 8 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Beata Kosmider, PhD

Research output

Search results