Personal profile
Research interests
Dr. Kosmider’s translational research interests center on primary alveolar type II cells. These cells make and secrete pulmonary surfactants, and proliferate to restore the epithelium after damage to the more sensitive alveolar type I cells.
Dr. Kosmider isolates alveolar type II cells from human and murine lungs to determine the mechanism of cell injury and impaired repair after exposure to various factors such as cigarette smoke, e-cigarette aerosols, bacterial and viral infections.
Dr. Kosmider’s laboratory analyzes the inflammatory response and antioxidant defense system in these cells -- using cellular, molecular biology, and biochemistry approaches – and focuses on strategies to enhance alveolar type II cell proliferation and differentiation for lung regeneration after injury.
In addition, Dr. Kosmider studies the mechanism of pulmonary emphysema development and progression. Emphysema is characterized by the loss of alveolar structure and air space enlargement. As therapy for this disease is limited, a deeper understanding of emphysema pathogenesis could lead to novel treatments to slow down alveolar wall destruction.
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Collaborations and top research areas from the last five years
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A comprehensive analysis of immune checkpoint receptor–ligand pairs in aortic diseases highlights the immunosuppressive roles of CD155 and CD274
Shao, Y., Saaoud, F., Xu, K., Lu, Y., Wu, S., Martinez, L., Vazquez-Padron, R., Kosmider, B., Wang, H. & Yang, X., Mar 2026, In: Genes and Diseases. 13, 2, p. 101724 101724.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
Lin, C. R., Hayek, H., Simborio, H., Karim, L., Bahmed, K., Bolla, S., Marchetti, N., Criner, G. J., Tian, Y. & Kosmider, B., Feb 1 2026, In: Aging and Disease. 17, 1, p. 367-382 16 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Chronic obstructive pulmonary disease reprograms the lung into an immune organ through trained immunity, cell death networks, and immune checkpoint dysregulation
Saaoud, F., Xu, K., Lu, Y., Shao, Y., Han, B., Wang, X., Jiang, X., Liu, X., Du, J., Wang, H., Kosmider, B. & Yang, X., 2026, In: Frontiers in Medicine. 13, p. 1721780 1721780.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deletion of STIM1 in Treg cells protects against lung fibrosis and associated cardiovascular complications in a pre-clinical mouse model
Nagre, N., Srinivas, B., Richards, N., Washington, R., Nicholson, G., Sanders, Y., Kosmider, B. & Matrougui, K., May 2026, In: Redox Biology. 92, p. 104117 104117.Research output: Contribution to journal › Article › peer-review
Open Access -
New approaches to uncover COPD pathobiology and develop therapies
Tesfaigzi, Y., Yildirim, A. Ö., Polverino, F., Conlon, T. M., Sidhaye, V., Sauler, M., Raju, S. V., Jurkowska, R. Z., Chandra, D., Cho, M. H., Silverman, E. K., Sun, R. C., Castaldi, P., Tata, P. R., Benam, K. H., Antony, L., Lehmann, M., Kosmider, B., Bahmed, K. & Negasi, Z. H. & 11 others, , Feb 23 2026, In: JCI insight. 11, 4Research output: Contribution to journal › Review article › peer-review
Open Access