Research output per year
Research output per year
Personal profile
Research Interests
Lab Overview
The research program in the Abdul-Aziz lab focuses on understanding the molecular mechanisms involved in the aging bone marrow microenvironment (BMM) niche and the role of aged microenvironment cells in promoting adult myeloid leukemia development and response to therapy.
Using patient tumor cells and in in vitro as well as in vivo assays, the lab aims to uncover intrinsic mechanisms in the mesenchymal stromal cell and immune cell components of the BMM that are associated with natural and leukemia-induced aging.
The lab also places a large emphasis on investigating the effect of targeted leukemia therapies on components of the bone marrow microenvironment with the goal to understand mechanisms of resistance and relapse that are microenvironment driven.
URL
URL
Fingerprint
Dive into the research topics where Amina Abdul-Aziz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Inhibition of Enhancer of Zeste Homolog 2 Induces Blast Differentiation, Impairs Engraftment and Prolongs Survival in Murine Models of Acute Myeloid Leukemia
Fobare, S., Elgamal, O. A., Wunderlich, M., Stahl, E., Mehmood, A., Furby, C., Lerma, J. R., Sesterhenn, T. M., Pan, J., Rai, J., Johnstone, M. E., Abdul-Aziz, A., Johnson, M. L., Rai, S. N., Byrd, J. C. & Hertlein, E., Feb 2024, In: Cancers. 16, 3, 569.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mass Cytometry as a Tool for Investigating Senescence in Multiple Model Systems
Abdul-Aziz, A., Devine, R. D., Lyberger, J. M., Chang, H., Kovacs, A., Lerma, J. R., Rogers, A. M., Byrd, J. C., Hertlein, E. & Behbehani, G. K., Aug 2023, In: Cells. 12, 16, 2045.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
Abdul-Aziz, A. M., Sun, Y., Hellmich, C., Marlein, C. R., Mistry, J., Forde, E., Piddock, R. E., Shafat, M. S., Morfakis, A., Mehta, T., Di Palma, F., Macaulay, I., Ingham, C. J., Haestier, A., Collins, A., Campisi, J., Bowles, K. M. & Rushworth, S. A., Jan 31 2019, In: Blood. 133, 5, p. 446-456 11 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia
Abdul-Aziz, A. M., Shafat, M. S., Sun, Y., Marlein, C. R., Piddock, R. E., Robinson, S. D., Edwards, D. R., Zhou, Z., Collins, A., Bowles, K. M. & Rushworth, S. A., May 2018, In: Oncogene. 37, 20, p. 2676-2686 11 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC
Piddock, R. E., Marlein, C. R., Abdul-Aziz, A., Shafat, M. S., Auger, M. J., Bowles, K. M. & Rushworth, S. A., Apr 16 2018, In: Journal of hematology & oncology. 11, 1, p. 66Research output: Contribution to journal › Article › peer-review
23 Scopus citations