The Center for Immunology is historically rooted in investigations of immune function during chronic diseases, including viral infections and cancers, and in hematopoietic and lymphoid development. The Center is headed by Siddharth Balachandran and David Wiest as Basic Science Co-Directors. New and established collaborations between CFI members and those in other Programs (e.g., NDC and CTM) and Institutes (e.g., CEI) accelerate the translation of basic science observations. Progress toward this goal is is aided by the inclusion of clinicians and clinical scientists interested in mobilizing lab-based findings for rapid translation into immunotherapy-related clinical trials. These translational efforts are shepherded by Clinical Science Co-Directors, Igor Astsaturov and Matt Zibelman. Ongoing CFI research focuses on how perturbation of the processes controlling the specification of normal cell fate leads to blood cancers, how inflammation within tumors may accelerate tumor promotion or growth, and how unique interactions between immune effectors and their targets can be exploited to improve cancer immunotherapy. We believe that understanding basic mechanisms of immune development and function will catalyze new opportunities for cancer treatment. The Center for Immunology's leaders are Siddharth Balachandran, PhD, David Wiest, PhD, Matthew R. Zibelman, MD, and Igor Astsaturov, MD, PhD.