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Search results
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2024
PAK2 is necessary for myelination in the peripheral nervous system
Hu, B., Moiseev, D., Schena, I., Faezov, B., Dunbrack, R., Jonathan, C. & Li, J., May 1 2024, In: Brain. 147, 5, p. 1809-1821 13 p., awad413.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2023
Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing
Demidova, E. V., Serebriiskii, I. G., Vlasenkova, R., Kelow, S., Andrake, M. D., Hartman, T. R., Kent, T., Virtucio, J., Rosen, G. L., Pomerantz, R. T., Dunbrack, R. L., Golemis, E. A., Hall, M. J., Chen, D. Y. T., Daly, M. B. & Arora, S., Mar 24 2023, In: Bmc Genomics. 24, 1, p. 212 212.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth
Tang, R., Shuldiner, E. G., Kelly, M., Murray, C. W., Hebert, J. D., Andrejka, L., Tsai, M. K., Hughes, N. W., Parker, M. I., Cai, H., Li, Y. C., Wahl, G. M., Dunbrack, R. L., Jackson, P. K., Petrov, D. A. & Winslow, M. M., Jan 2023, In: Nature Cell Biology. 25, 1, p. 159-169 11 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons
Hernandez, L. M., Montersino, A., Niu, J., Guo, S., Faezov, B., Sanders, S. S., Dunbrack, R. L. & Thomas, G. M., Aug 2023, In: Journal of Biological Chemistry. 299, 8, p. 104965 104965.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2022
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Zhang, T., Yin, C., Fedorov, A., Qiao, L., Bao, H., Beknazarov, N., Wang, S., Gautam, A., Williams, R. M., Crawford, J. C., Peri, S., Studitsky, V., Beg, A. A., Thomas, P. G., Walkley, C., Xu, Y., Poptsova, M., Herbert, A. & Balachandran, S., Jun 2022, In: Nature. 606, 7914, p. 594-602 9 p.Research output: Contribution to journal › Article › peer-review
Open Access334 Scopus citations -
Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers
Serebriiskii, I. G., Pavlov, V., Tricarico, R., Andrianov, G., Nicolas, E., Parker, M. I., Newberg, J., Frampton, G., Meyer, J. E. & Golemis, E. A., Dec 2022, In: Nature Communications. 13, 1, 1618.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Development and Utility of a PAK1-Selective Degrader
Chow, H. Y., Karchugina, S., Groendyke, B. J., Toenjes, S., Hatcher, J., Donovan, K. A., Fischer, E. S., Abalakov, G., Faezov, B., Dunbrack, R., Gray, N. S. & Chernoff, J., Nov 8 2022, In: Journal of Medicinal Chemistry. 65, 23, p. 15627-15641 15 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency
Sertori, R., Lin, J. X., Martinez, E., Rana, S., Sharo, A., Kazemian, M., Sunderam, U., Andrake, M., Shinton, S., Truong, B., Dunbrack, R. M., Liu, C., Srinivasan, R., Brenner, S. E., Seroogy, C. M., Puck, J. M., Leonard, W. J. & Wiest, D. L., Jul 29 2022, In: Frontiers in Immunology. 13, p. 928252 928252.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm
Zhang, Y., Truong, B., Fahl, S. P., Martinez, E., Cai, K. Q., Al-Saleem, E. D., Gong, Y., Liebermann, D. A., Soboloff, J., Dunbrack, R., Levine, R. L., Fletcher, S., Kappes, D., Sykes, S. M., Shapiro, P. & Wiest, D. L., Jul 28 2022, In: Blood. 140, 4, p. 359-373 15 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2021
Pp2a/b55a substrate recruitment as defined by the retinoblastoma-related protein p107
Fowle, H., Zhao, Z., Xu, Q., Wasserman, J. S., Wang, X., Adeyemi, M., Feiser, F., Kurimchak, A., Atar, D., McEwan, B. C., Kettenbach, A. N., Page, R., Peti, W., Dunbrack, R. L. & Grana, X., Oct 2021, In: eLife. 10, e63181.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Structure of TFIIK for phosphorylation of CTD of RNA polymerase II
van Eeuwen, T., Li, T., Kim, H. J., Gorbea Colón, J. J., Parker, M. I., Dunbrack, R. L., Garcia, B. A., Tsai, K. L. & Murakami, K., Apr 7 2021, In: Science Advances. 7, 15, eabd4420.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2020
Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism - inhibitory effect of LGM2605
Mishra, O. P., Popov, A. V., Pietrofesa, R. A., Hwang, W. T., Andrake, M., Nakamaru-Ogiso, E. & Christofidou-Solomidou, M., Jul 2020, In: Biochimica et Biophysica Acta - General Subjects. 1864, 7, p. 129548 129548.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting
Dunlevy, K. L., Medvedeva, V., Wilson, J. E., Hoque, M., Pellegrin, T., Maynard, A., Kremp, M. M., Wasserman, J. S., Poleshko, A. & Katz, R. A., May 27 2020, In: Journal of Cell Science. 133, 10, 240416.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2019
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients
Serebriiskii, I. G., Connelly, C., Frampton, G., Newberg, J., Cooke, M., Miller, V., Ali, S., Ross, J. S., Handorf, E., Arora, S., Lieu, C., Golemis, E. A. & Meyer, J. E., Dec 1 2019, In: Nature Communications. 10, 1, 3722.Research output: Contribution to journal › Article › peer-review
Open Access192 Scopus citations -
Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma
Nicolas, E., Demidova, E. V., Iqbal, W., Serebriiskii, I. G., Vlasenkova, R., Ghatalia, P., Zhou, Y., Rainey, K., Forman, A. F., Dunbrack, R. L., Golemis, E. A., Hall, M. J., Daly, M. B. & Arora, S., Jan 2019, In: Molecular Genetics and Genomic Medicine. 7, 3, p. e556 e556.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Protein modeling to assess the pathogenicity of rare variants of SERPINA1 in patients suspected of having Alpha 1 Antitrypsin Deficiency
Kueppers, F., Andrake, M. D., Xu, Q., Dunbrack, R. L., Kim, J. & Sanders, C. L., Jul 15 2019, In: BMC Medical Genetics. 20, 1, p. 125 125.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations