Research Resources Details
Description
The overall purpose of the Molecular Modeling Facility (MMF) is to enable the design and interpretation of experiments in all areas of cancer biology in the laboratories of Cancer Center members through the analysis of experimental and predicted three-dimensional structures of proteins and protein complexes. The Molecular Modeling Facility assists investigators in predicting the effects of missense mutations and provides structural information on proteins that may be good targets for the development of therapeutics. The Facility uses state-of-the-art structure prediction tools, including the recently developed AlphaFold2 from DeepMind. The Facility provides assistance with graphical images of experimental and predicted protein structures as well as text for grants and publications correlating structural information with biological outcomes.
This facility derives partial funding from the FCCC Cancer Center Support Grant (CCSG) from the National Cancer Institute.
This facility derives partial funding from the FCCC Cancer Center Support Grant (CCSG) from the National Cancer Institute.
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Explore the research areas in which this equipment has been used. These labels are generated based on the related outputs. Together they form a unique fingerprint.
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PAK2 is necessary for myelination in the peripheral nervous system
Hu, B., Moiseev, D., Schena, I., Faezov, B., Dunbrack, R., Jonathan, C. & Li, J., May 1 2024, In: Brain. 147, 5, p. 1809-1821 13 p., awad413.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Candidate variants in DNA replication and repair genes in early-onset renal cell carcinoma patients referred for germline testing
Demidova, E. V., Serebriiskii, I. G., Vlasenkova, R., Kelow, S., Andrake, M. D., Hartman, T. R., Kent, T., Virtucio, J., Rosen, G. L., Pomerantz, R. T., Dunbrack, R. L., Golemis, E. A., Hall, M. J., Chen, D. Y. T., Daly, M. B. & Arora, S., Mar 24 2023, In: Bmc Genomics. 24, 1, p. 212 212.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55⍺/PP2A phosphatase
Wasserman, J. S., Faezov, B., Patel, K. R., Kurimchak, A. N., Palacio, S. M., Fowle, H., McEwan, B. C., Xu, Q., Zhao, Z., Cressey, L., Johnson, N., Duncan, J. S., Kettenbach, A. N., Dunbrack, R. L. & Grana, X., 2023, (bioRxiv : the preprint server for biology).Research output: Working paper › Preprint