Research Resources Details
Description
The Histopathology Facility (HF) provides Cancer Center members with technical processing of cells and tissues, gene expression in situ protein immunolocalization, pathology interpretation of microscopy findings, including target distribution and other metrics focused on particular cell/tissue compartments. We help establish and characterize animal models of human cancer and related diseases, as well as analysis of human tissue samples, including from clinical trials. Most projects involve animal models that require complex histological, immunohistochemical and/or cytological processing to determine morphological alterations, and to localize and quantify the expression of cancer-relevant gene products in tissue sections, including murine and human samples.
This facility derives partial funding from the FCCC Cancer Center Support Grant (CCSG) from the National Cancer Institute.
This facility derives partial funding from the FCCC Cancer Center Support Grant (CCSG) from the National Cancer Institute.
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ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment
Flashner, S., Shimonosono, M., Tomita, Y., Matsuura, N., Ohashi, S., Muto, M., Klein-Szanto, A. J. P., Diehl, J. A., Chen, C.-H., Mochly-Rosen, D., Weinberg, K. I. & Nakagawa, H., Feb 12 2024, In: Carcinogenesis. 45, 1-2, p. 95-106 12 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
SAR-096: Phase II clinical trial of ribociclib in combination with everolimus in advanced dedifferentiated liposarcoma (DDL), and leiomyosarcoma (LMS): Phase II Clinical Trial of Ribociclib in Combination with Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
Movva, S., Matloob, S., Handorf, E. A., Choy, E., Merriam, P., Flieder, D. B., Cai, K. Q., Zhou, Y., Tetzlaff, E. D., Pagan, C., Barker, E., Veggeberg, R., Zumpano, D., Rink, L., von Mehren, M. & George, S., Jan 15 2024, In: Clinical Cancer Research. 30, 2, p. 315-322 8 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Analysis and therapeutic targeting of the IL-1R pathway in anaplastic large cell lymphoma
Song, Z., Wu, W., Wei, W., Xiao, W., Lei, M., Cai, K. Q., Huang, D. W., Jeong, S., Zhang, J. P., Wang, H., Kadin, M. E., Waldmann, T. A., Staudt, L. M., Nakagawa, M. & Yang, Y., Oct 12 2023, In: Blood. 142, 15, p. 1297-1311 15 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations