High Throughput Screening Facility

2023

A phase 1 study of nivolumab in combination with interferon-gamma for patients with advanced solid tumors

Zibelman, M., MacFarlane, A. W., Costello, K., McGowan, T., O’Neill, J., Kokate, R., Borghaei, H., Denlinger, C. S., Dotan, E., Geynisman, D. M., Jain, A., Martin, L., Obeid, E., Devarajan, K., Ruth, K., Alpaugh, R. K., Dulaimi, E. A. S., Cukierman, E., Einarson, M. & Campbell, K. S. & 1 others, Plimack, E. R., Jun 27 2023, In: Nature Communications. 14, 1, p. 4513 4513.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Loss of Pkd1 limits susceptibility to colitis and colorectal cancer

Nikonova, A. S., Deneka, A. Y., Silva, F. N., Pirestani, S., Tricarico, R., Kiseleva, A., Zhou, Y., Nicolas, E., Flieder, D. B., Grivennikov, S. I. & Golemis, E. A., Jul 5 2023, In: Oncogenesis. 12, 1, p. 40 40.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype

Tricarico, R., Madzo, J., Scher, G., Cohen, M., Jelinek, J., Maegawa, S., Nagarathinam, R., Scher, C., Chang, W. C., Nicolas, E., Slifker, M., Zhou, Y., Devarajan, K., Cai, K. Q., Kwok, T., Nakajima, P., Xu, J., Mancuso, P., Doneddu, V. & Bagella, L. & 21 others, Williams, R., Balachandran, S., Maskalenko, N., Campbell, K., Ma, X., Cañadas, I., Viana-Errasti, J., Moreno, V., Valle, L., Grivennikov, S., Peshkova, I., Kurilenko, N., Mazitova, A., Koltsova, E., Lee, H., Walsh, M., Duttweiler, R., Whetstine, J. R., Yen, T. J., Issa, J. P. & Bellacosa, A., May 2023, In: Gastroenterology. 164, 6, p. 921-936.e1

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2022

Correction to: Thymine DNA glycosylase as a novel target for melanoma (Oncogene, (2019), 38, 19, (3710-3728), 10.1038/s41388-018-0640-2)

Mancuso, P., Tricarico, R., Bhattacharjee, V., Cosentino, L., Kadariya, Y., Jelinek, J., Nicolas, E., Einarson, M., Beeharry, N., Devarajan, K., Katz, R. A., Dorjsuren, D. G., Sun, H., Simeonov, A., Giordano, A., Testa, J. R., Davidson, G., Davidson, I., Larue, L. & Sobol, R. W. & 2 others, Yen, T. J. & Bellacosa, A., May 2022, In: Oncogene. 41, 23, p. 3300-3301 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

NEDD9 sustains hexokinase expression to promote glycolysis

Deneka, A. Y., Nikonova, A. S., Lee, H. O., Kruger, W. D. & Golemis, E. A., Mar 11 2022, In: Oncogenesis. 11, 1, p. 15 15.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells

Kurimchak, A. M., Herrera-Montávez, C., Montserrat-Sangrà, S., Araiza-Olivera, D., Hu, J., Neumann-Domer, R., Kuruvilla, M., Bellacosa, A., Testa, J. R., Jin, J. & Duncan, J. S., Aug 30 2022, In: Science Signaling. 15, 749, p. eabn2707 eabn2707.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

2021

Combined inhibition of AKT and KIT restores expression of programmed cell death 4 (PDCD4) in gastrointestinal stromal tumor

Kozinova, M., Joshi, S., Ye, S., Belinsky, M. G., Sharipova, D., Farma, J. M., Reddy, S. S., Litwin, S., Devarajan, K., Campos, A. R., Yu, Y., Schwartz, B., von Mehren, M. & Rink, L., Jun 23 2021, In: Cancers. 13, 15, 3699.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Evaluation of the small-molecule BRD4 degrader CFT-2718 in small-cell lung cancer and pancreatic cancer models

Golemis, E. A., Sun, D., Nikonova, A. S., Zhang, P., Deneka, A. Y., Fitzgerald, M. E., Michael, R. E., Lee, L., Lilly, A. C., Fisher, S. L., Phillips, A. J., Nasveschuk, C. G., Proia, D. A. & Tu, Z., Aug 2021, In: Molecular Cancer Therapeutics. 20, 8, p. 1367-1377 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

High Variability in Cellular Proliferation, Gene Expression, and Cytokine Production in the Nonneoplastic Colonic Epithelium of Young Apc^+/Min-FCCC Mice

Leystra, A. A., Harvey, K. N., Kaunga, E., Hensley, H., Vanderveer, L. A., Devarajan, K. & Clapper, M. L., Aug 27 2021, In: Frontiers in Oncology. 11, p. 705562 705562.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment

Ye, S., Sharipova, D., Kozinova, M., Klug, L., D’Souza, J., Belinsky, M. G., Johnson, K. J., Einarson, M. B., Devarajan, K., Zhou, Y., Litwin, S., Heinrich, M. C., DeMatteo, R., von Mehren, M., Duncan, J. S. & Rink, L., Dec 25 2021, In: JCI insight. 6, 2, e143474.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC)

Makhov, P., Nicolas, E., Borghaei, H., Edelman, M., Golemis, E. A., Bychkov, I., Faezov, B., Deneka, A. Y., Kudinov, A. E., Brebion, R., Avril, E., Cai, K., Kharin, L. V., Voloshin, M., Frantsiyants, E., Karnaukhov, N., Kit, O. I., Topchu, I., Fazliyeva, R. & Nikonova, A. S. & 3 others, Serebriiskii, I. G., Dulaimi, E. & Boumber, Y., Mar 2021, In: Oncogenesis. 10, 3, p. 29 29.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma

Alexander, J. I., Vendramini-Costa, D. B., Francescone, R., Luong, T., Franco-Barraza, J., Shah, N., Gardiner, J. C., Nicolas, E., Raghavan, K. S. & Cukierman, E., Jan 15 2021, In: Scientific Reports. 11, 1, p. 3802 3802.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM

Cho, E. A., Zhang, P., Kumar, V., Kavalchuk, M., Zhang, H., Huang, Q., Duncan, J. S. & Wu, J., Apr 1 2021, In: Structure. 29, 4, p. 320-329.e4

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2020

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

Gabitova-Cornell, L., Surumbayeva, A., Peri, S., Franco-Barraza, J., Restifo, D., Weitz, N., Ogier, C., Goldman, A., Hartman, T. R., Francescone, R., Tan, Y., Nicolas, E., Shah, N., Handorf, E., Cai, K., O'Reilly, A. M., Sloma, I., Chiaverelli, R., Moffitt, R. & Khazak, V. & 4 others, Fang, C. Y., Golemis, E. A., Cukierman, E. & Astsaturov, I., Oct 12 2020, In: Cancer Cell. 38, 4, p. 567-583.e11

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma

Makhov, P., Sohn, J., Serebriiskii, I., Fazliyeva, R., Khazak, V., Boumber, Y., Uzzo, R. G. & Kolenko, V. M., Nov 2020, In: British Journal of Cancer. 123, 12, p. 1749-1756 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma

Kurimchak, A. M., Herrera-Montávez, C., Brown, J., Johnson, K. J., Sodi, V. L., Srivastava, N., Kumar, V., Deihimi, S., O'Brien, S., Peri, S., Mantia-Smaldone, G. M., Jain, A., Winters, R. M., Cai, K. Q., Chernoff, J., Connolly, D. C. & Duncan, J. S., Feb 18 2020, In: Science Signaling. 13, 619, eaax8238.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Prevalence of pathogenic variants in DNA damage response and repair genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer

Hartman, T. R., Demidova, E. V., Lesh, R. W., Hoang, L., Richardson, M., Forman, A., Kessler, L., Speare, V., Golemis, E. A., Hall, M. J., Daly, M. B. & Arora, S., Aug 2020, In: Scientific Reports. 10, 1, p. 13518 13518.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Synthetic lethal targeting of mitotic checkpoints in HPV-negative head and neck cancer

Deneka, A. Y., Einarson, M. B., Bennett, J., Nikonova, A. S., Elmekawy, M., Zhou, Y., Lee, J. W., Burtness, B. A. & Golemis, E. A., Feb 2020, In: Cancers. 12, 2, 306.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2019

Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck

Lee, J. W., Parameswaran, J., Sandoval-Schaefer, T., Eoh, K. J., Yang, D. H., Zhu, F., Mehra, R., Sharma, R., Gaffney, S. G., Perry, E. B., Townsend, J. P., Serebriiskii, I. G., Golemis, E. A., Issaeva, N., Yarbrough, W. G., Koo, J. S. & Burtness, B., Jun 1 2019, In: Clinical Cancer Research. 25, 11, p. 3430-3442 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

Korobeynikov, V., Borakove, M., Feng, Y., Wuest, W. M., Koval, A. B., Nikonova, A. S., Serebriiskii, I., Chernoff, J., Borges, V. F., Golemis, E. A. & Shagisultanova, E., Sep 15 2019, In: Breast Cancer Research and Treatment. 177, 2, p. 369-382 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Enhanced SLAMF7 homotypic interactions by elotuzumab improves NK cell killing of multiple myeloma

Pazina, T., James, A. M., Colby, K. B., Yang, Y., Gale, A., Jhatakia, A., Kearney, A. Y., Graziano, R. F., Bezman, N. A., Robbins, M. D., Cohen, A. D. & Campbell, K. S., 2019, In: Cancer Immunology Research. 7, 10, p. 1633-1646 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening

Martin, D. D. O., Kanuparthi, P. S., Holland, S. M., Sanders, S. S., Jeong, H. K., Einarson, M. B., Jacobson, M. A. & Thomas, G. M., Feb 6 2019, In: Scientific Reports. 9, 1, p. 3632 3632.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Microscopy-Based automated live cell screening for small molecules that affect ciliation

Einarson, M. B., Golemis, E. A., Zhang, P., Kiseleva, A., Korobeynikov, V. A. & Liu, H., 2019, In: Frontiers in Genetics. 10, FEB, p. 75 75.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation

Chang, Y. C., Su, W., Cho, E. A., Zhang, H., Huang, Q., Philips, M. R. & Wu, J., Feb 26 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3524-3529 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility

Cukierman, E., Kaur, A., Ecker, B. L., Douglass, S. M., Kugel, C. H., Webster, M. R., Almeida, F., Somasundaram, R., Hayden, J., Ban, E., Ahmadzadeh, H., Franco-Barraza, J., Shah, N., Mellis, I. A., Keeney, F., Kossenkov, A., Tang, H. Y., Yin, X., Liu, Q. & Xu, X. & 10 others, Fane, M., Brafford, P., Herlyn, M., Speicher, D. W., Wargo, J. A., Tetzlaff, M. T., Haydu, L. E., Raj, A., Shenoy, V. B. & Weeraratna, A. T., Jan 2019, In: Cancer Discovery. 9, 1, p. 64-81 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

288 Scopus citations

Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2

Malik, R., Luong, T., Cao, X., Han, B., Shah, N., Franco-Barraza, J., Han, L., Shenoy, V. B., Lelkes, P. I. & Cukierman, E., Aug 2019, In: Matrix Biology. 81, p. 50-69 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition

Gabbasov, R., Benrubi, I. D., O'Brien, S. W., Krais, J. J., Johnson, N., Litwin, S. & Connolly, D. C., Jul 3 2019, In: Cancer Biology and Therapy. 20, 7, p. 1035-1045 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Thymine DNA glycosylase as a novel target for melanoma

Mancuso, P., Tricarico, R., Bhattacharjee, V., Cosentino, L., Kadariya, Y., Jelinek, J., Nicolas, E., Einarson, M., Beeharry, N., Devarajan, K., Katz, R. A., Dorjsuren, D. G., Sun, H., Simeonov, A., Giordano, A., Testa, J. R., Davidson, G., Davidson, I., Larue, L. & Sobol, R. W. & 2 others, Yen, T. J. & Bellacosa, A., Apr 2019, In: Oncogene. 38, 19, p. 3710-3728 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs

Makhov, P., Einarson, M. B., Golemis, E. A., Kiseleva, A., Korobeynikov, V. A., Nikonova, A. S., Zhang, P., Deneka, A. Y., Serebriiskii, I. G., Liu, H. & Peterson, J. R., 2019, In: Clinical Cancer Research. 25, 13, p. 4179-4193 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

High Throughput Screening Facility

Research output

Search results