Research Resources Details
Description
The Cell Culture Facility provides reagents, equipment, technical expertise, consultation and training to support mammalian cell culture experiments at Fox Chase. Services include:
This facility derives partial funding from the FCCC Cancer Center Support Grant (CCSG) from the National Cancer Institute.
1. Basic cell culture support: cell banking, detection of mycoplasma contamination in cultured cells, cell line validation support, and maintenance of >150 common STR-authenticated cell lines
2. On-request establishment of 3D organoid cultures and primary cultures from human and animal tissue samples
3. Hybridoma production to generate monoclonal antibodies
4. Preparation of sterile growth media and reagents
Specialized equipment: electroporators, cell counter, xCELLigence, low oxygen incubation, Incucyte SX5, Hypoxic culture chamber.
Dr. Tim Kwok (until September, 2025) is responsible for the day-to-day management of the CCF, consultation support, project management, direct supervision of the work of staff members, and cell culture services for organoid cultures.
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Explore the research areas in which this equipment has been used. These labels are generated based on the related outputs. Together they form a unique fingerprint.
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A CRISPR-based system to investigate HBV cccDNA biology
Seeger, C., Oct 2023, In: Journal of Virology. 97, 10Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Analysis and therapeutic targeting of the EP300 and CREBBP acetyltransferases in anaplastic large cell lymphoma and Hodgkin lymphoma
Wei, W., Song, Z., Chiba, M., Wu, W., Jeong, S., Zhang, J. P., Kadin, M. E., Nakagawa, M. & Yang, Y., Jan 2023, In: Leukemia. 37, 2, p. 396-407 12 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Analysis and therapeutic targeting of the IL-1R pathway in anaplastic large cell lymphoma
Song, Z., Wu, W., Wei, W., Xiao, W., Lei, M., Cai, K. Q., Huang, D. W., Jeong, S., Zhang, J. P., Wang, H., Kadin, M. E., Waldmann, T. A., Staudt, L. M., Nakagawa, M. & Yang, Y., Oct 12 2023, In: Blood. 142, 15, p. 1297-1311 15 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations